Major work to three Salford roads will start from Monday, April 12 and will last approximately six months.
Salford City Council says the £1.3 million scheme to resurface the A6 Chapel Street is necessary to stop the road from deteriorating further.
It was repaved with granite blocks in 2011/2012, but they have become damaged over time and need to be replaced.
The cost will be part-funded by a financial settlement agreed between Salford City Council and Urban Vision/Galliford Try which carried out the original work.
The resurfacing work, which will affect Chapel Street between Trinity Way (the inner ring road) and Oldfield Road will be carried out under lane closures starting from Monday, April 19, and using a contraflow which will be introduced from Monday, May 3.
A new layby in Great George Street will be created as part of the scheme to provide parking for funeral corteges at Salford Cathedral and avoid vehicles stopping on Chapel Street itself.
Great George Street will be closed at its junction with the A6 Chapel Street for a few weeks during the six-month period to facilitate this.
Traffic exiting or seeking to enter Islington Way will be via signed diversion routes.
Meanwhile, work to improve cycling and walking routes along Liverpool Street will begin in April after the Greater Manchester Combined Authority approved the final funding needed for the £3.1 million scheme last month.
The Liverpool Road scheme will maintain the road space for motorists but increase space for pedestrians and cyclists and will introduce new crossing and bus boarding facilities.
The road will remain open as normal with two-way running for the first phase.
Work to complete the terraced footway/cycleway on Middlewood Street, which has been delayed by building work, will also go ahead in May. The road will be open one way for traffic to Manchester but closed at its junction with Trinity Way to Salford bound traffic.
Ben Dolan, Strategic Director Place, said: “These are major and complex schemes which have taken months of detailed planning to put together.
“We will get a good head start on them before lockdown measures are due to be lifted fully in June, although we anticipate many people will continue to work from home or continue walking or cycling as they have done through lockdown.
“However some disruption to traffic is inevitable and we apologise for that but it cannot be avoided if this road is to be restored and work carried out. Access to businesses and homes in the area will be maintained.”